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Index > Protein center > PLCZ1(Gene name) > Bovine
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  • PLCZ1 (Gene name),
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 (Protein name ),  PLCZ1_BOVIN from NCBI database.
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  • Gene name:
    PLCZ1(PLCZ);
    Protein name:
    1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1;
    Alternative:
    Phospholipase C-zeta-1(PLC-zeta-1);Phosphoinositide phospholipase C-zeta-1;
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Interacts (via its C2 domain) with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
    Function:
    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
    Subcellular Location:
    Nucleus Cytoplasm perinuclear region Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis.
    Protein Attributes:
    Sequence length:
    634
    Sequence:
    50:
    MENKWFLLMV | RDDFKGGKIT | LEKALKLLEK | LDIQCNTIHV | KYIFKDNDRL | 
    100:
    KQGRITIEEF | RTIYRIITYR | EEIIEIFNTY | SENRKILLEK | NLVEFLMREQ | 
    150:
    YTLDFNKSIA | SEIIQKYEPI | EEVKQAHQMS | FEGFRRYMDS | SECLLFDNKC | 
    200:
    DHVYQDMTHP | LTDYFISSSH | NTYLISDQLW | GPSDLWGYIS | ALVKGCRCLE | 
    250:
    IDCWDGSQNE | PVVYHGYTFT | SKLLFKTVIQ | AINKYAFLAS | EYPVVLSLEN | 
    300:
    HCSPSQQEVM | ADSLLATFGD | ALLSYTLDNF | SDRLPSPEAL | KFKILVRNKK | 
    350:
    IGTLHETLER | KGSDMHGKVE | EFEEEEEIEQ | EEDGSGAKEP | EPVGDFQDDL | 
    400:
    AKEEQLKRVV | GIPLFRKKKI | KISMALSDLV | IYTKVEKFKS | FHHSHLYQQF | 
    450:
    NESNSIGESQ | ARKLTKLAAR | EFILHTRRFI | TRVYPKALRA | DSSNFNPQEF | 
    500:
    WNVGCQMVAL | NFQTPGVPMD | LQNGKFLDNG | CSGYVLKPRF | LRDKKTKFNP | 
    550:
    HKVQIDSNPL | TLTIRLISGI | QLPPSYQNKA | DTLVIVEIFG | VPNDQMKQQS | 
    600:
    RVIKKNAFNP | RWNETFTFVI | QVPELALIRF | VAENQGLIAG | NEFLGQYTLP | 
    634:
    VLCMNRGYRR | VPLFSKMGES | LEPASLFIYV | WYIR
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    E15484h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    E15484c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    E15484m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    E15484r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    E15484b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    U15484m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    U15484h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    U15484r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    U15484c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    U15484b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    P15484Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    P15484Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    P15484Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

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    Linearity
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    References
    1. 1.
      "Molecular cloning and characterization of PLC-zeta in cattle."
      Kumar K.G. , Chomdej S. , Wimmers K. , Schellander K.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      NIH - Mammalian Gene Collection (MGC) project
      Submitted (2006-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Crossbred X Angus.
      tissue: Liver.
    3. 3.
      "Fertilization and inositol 1,4,5-trisphosphate (IP3)-induced calcium release in type-1 inositol 1,4,5-trisphosphate receptor down-regulated bovine eggs."
      Malcuit C. , Knott J.G. , He C. , Wainwright T. , Parys J.B. , Robl J.M. , Fissore R.A.
      Biol. Reprod.73:2-13(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    4. 4.
      "Parthenogenetic activation of bovine oocytes using bovine and murine phospholipase C zeta."
      Ross P.J. , Beyhan Z. , Iager A.E. , Yoon S.-Y. , Malcuit C. , Schellander K. , Fissore R.A. , Cibelli J.B.
      BMC Dev. Biol.8:16-16(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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